Abnormal limb swelling caused by the accumulation of increased amounts of high protein ISF secondary  to defective lymphatic drainage in the presence of normal net capillary  filtration.

Lymphedema occurs when the lymphatic system is damaged or blocked. The fluid accumulates in the body’s soft tissues and causes swelling. This is a common problem that can be caused by cancer and its treatment. Lymphedema usually affects one arm or one leg, but it can also affect other parts of the body. Lymphedema can cause long-term physical, psychological and social problems to patients.

Lymphedema refers to a chronic non-pitting oedema due to lymphatic insufficiency. It is most commonly seen affecting the legs and tends to progress with age. Chronic disease may cause a secondary cobblestone thickening of skin.